Stereoselective Synthesis of Z-Fluoroalkenes by Copper-Catalyzed Hydrodefluorination of gem-Difluoroalkenes with Water
Release time:2017-08-31 clicks:1082
The group publishes a Stereoselective Synthesis of Z-Fluoroalkenes by Copper-Catalyzed Hydrodefluorination of gem-Difluoroalkenes with Water on Angew. Congrats Hu and Han!
ABSTRACT: A copper-catalytic system has been established for the stereoselective hydrodefluorination of gem-difluoroalkenes via C-F activation to synthesize various Z-fluoroalkenes. H2O is first used as a hydrogen source for the fluorine acceptor moiety. This mild catalytic system shows good functional group compatibility bearing substrates from aliphatic, aromatic and α,β-unsaturated aldehydes and even ketones that can be served as a powerful synthetic tool for late-stage modification of complex compounds.