Boron Trichloride-Mediated Synthesis of Indoles via the Aminoboration of Alkynes
Release time：2018-07-27 clicks：837
The group publishes an Boron Trichloride-Mediated Synthesis of Indoles via the Aminoboration of Alkynes on Adv. Synth. Catal. Congrats Lv and Zhao!
ABSTRACT: We describe an efficient catalyst- and metal-free aminoboration of alkynes to 3-borylated indoles using one of the least expensive boron sources, BCl3. The major dichloro(indolyl)borane products can be used for the in situ construction of useful 3-Bpin indoles. This simple and mild method provides a novel and efficient approach for the synthesis of various 3-borylated indoles with high regioselectivity and a wide substrate scope.
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